BioLines

Where Nature and Science Meet

biolines@africabio.com

Vol. 45                             

Sept 2003

Editor: M. Koch

 

AfricaBio

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BioLines is AfricaBio’s ‘Biotechnology Headlines’ – a quick guide to what is topical. By design, the articles are not exhaustive, but references are given to follow up points of interest. Let us know what you like and dislike about BioLines and what you want to see as part of this service. Articles are edited to meet space requirements. It is not the intention of this service to infringe on copyright. BioLines is issued free of charge and every effort is made to acknowledge the source of information.

 

 

CONTENTS:

 

¨       Cartagena Protocol on Biosafety takes effect (1)

¨       South Africa accedes to the Cartagena Protocol (3)

¨       CBD treaty disastrous (4)

¨       GM agreement in SADC (5)

¨       Contaminated organic maize meal withdrawn (5)

¨       GM fish produce Hepatitis vaccine (6)

¨       GM building materials (6)

¨       Pink bras can’t stop GM progress (7)

¨       GM market research called to higher ethics (8)

 

 

 

¨       Comparative Safety Assessment for Biotech Crops (9)

¨       Biotech contributes $33.5b to US GDP (9)

¨       EU publishes documents on GM safety assessment (9)

¨       Biotech and biodiversity in Malaysia (10)

¨       Biosafety strategy for GM crops in the Netherlands (10)

¨       Delayed ripening doubles shelf-life in banana (10)

¨       GM plant vaccine for asthma (11)

¨       Events (11)

________________________________________________________________­­­­­­­____________

 

Cartagena Protocol on Biosafety takes effect
UNEP Press Release. From AgBioView 9 Sep 03 (shortened)
http://www.biodiv.org/doc/press/presskits/bs/pr-01-en.pdf

The Cartagena Protocol on Biosafety, the first legally binding international agreement governing the transboundary movement of living modified organisms (LMOs) resulting from modern biotechnology
enters into force on 11 Sept 03. The treaty, which aims at ensuring an adequate level of protection in the field of the safe transfer, handling and use of LMOs resulting from modern biotechnology, was adopted in Jan 2000 by member countries to the Convention on Biological Diversity.

On 13 June this year, the
Republic of Palau became the 50th State to ratify the Protocol, which triggered the countdown to the entry into force. To date, 57 States and the European Community have ratified it, the Republic of SA being the most recent. Underscoring the significance of the Protocol's entry into force, CBD Executive Secretary Hamdallah Zedan said, "The Protocol has now become a binding instrument for States (Parties) that have given their consent to be bound by it". "This means that the transboundary movement of LMOs from one country to another will have to be in conformity with the provisions of the Protocol, in cases where both countries are Parties to the Protocol. However, in cases where movement of LMOs involves a Party and a non Party, such
movement shall be consistent with the objective of the Protocol., said Mr. Zedan.

"Because of the sensitivity and contention around some of the issues that almost made it impossible to have agreement on the text of the Protocol until the very last minute, some skeptics were wondering if the Protocol, even though adopted, would ever enter into force. Well, they have been
proven wrong", said Ambassador Philemon Yang of
Cameroon. The Protocol establishes a harmonized set of international rules and procedures designed to ensure that countries are provided with the relevant information to enable them to make informed decisions before agreeing to the import of LMOs. It also ensures that LMO shipments are accompanied by appropriate identification documentation. The adoption of the Protocol in 2000 and now its entry into force have been significant steps. However, the major challenge now is the practical implementation of the provisions to enable the Protocol's objectives to be met. "All Parties need to take appropriate legal, administrative and other measures at the domestic level to translate the Protocol's provisions and objective into a practical reality", said Mr.Zedan.

Since the adoption of the Protocol, the Intergovernmental Committee on the Cartagena Protocol on Biosafety (ICCP) has made considerable progress in proposing possible implementation measures. ICCP is the interim body, established to undertake preparatory work for the first meeting of the
Protocol's decision-making body. "The work done by ICCP has contributed significantly to clarifying a number of issues thereby giving many countries the confidence they needed to ratify the Protocol and get ready for its implementation", said Ambassador Yang, the ICCP Chair. The decision-making body of all the member countries of the Protocol, the Conference of the Parties serving as the meeting of the Parties to the Protocol, will convene from 23 to 27 Feb 04 in Kuala Lumpur,
Malaysia to address strategic and operational measures for the implementation of the Protocol.

While the ultimate responsibility to ensure that the Protocol is implemented lies with Parties, Mr. Zedan observed that "all relevant stakeholders: business and industry, NGOs, scientists, researchers and the media have a big role to play". Their cooperation is essential for the successful implementation of the Protocol. "I encourage all the players to take on their respective responsibilities in support of the Protocol". "I strongly urge all countries that have not yet done so to ratify the Protocol as soon as possible in order that they may participate as full partners in the decision-making at the first meeting of Parties, which will shape the future of the Protocol".

Additional information

(1) The Cartagena Protocol on Biosafety was negotiated under the Convention on Biological Diversity in order to promote "the safe transfer, handling and use of LMOs resulting from modern biotechnology that may have adverse effects on the conservation and sustainable use of biological diversity, taking also into account risks to human health, and specifically focusing on transboundary movements".

(2) 103 countries signed the Protocol by the closing date for signature on 4 June 01.

(3) The entry into force of the Protocol means, in practical terms, that a number of things will change regarding the transboundary movement of LMOs, involving countries that are Parties to the Protocol:

(a) Under what is known as the advance informed agreement (AIA) procedure, any Party shipping LMOs for intentional introduction into the environment for the first time shall have to give prior notification to the importing country that is a party to the Protocol and provide sufficient information
to enable it to make an informed decision.

(b) On the other hand, if a Party approves for domestic use and marketing LMOs intended for direct use as food, feed or processing and these may be exported to other countries, that Party must communicate its decision and details about the LMOs to the world community via the Biosafety
Clearing-House (BCH).

(c) Furthermore, exporters must ensure that all shipments are accompanied by appropriate documentation required under the Protocol.

(d) Shipments of LMOs for intentional introduction into the environment will have to be identified in accompanying documentation as LMOs, with a specification of the LMO identity and characteristics and a declaration that "the movement is in conformity with the requirements of the Protocol”.

(e) The Biosafety Clearing-House is now operational. All decisions taken by any Party regarding the importation or release of LMOs must now be made available to the Biosafety Clearing-House. In addition, the information specified in the Protocol, including: national laws for implementing the
Protocol; any bilateral, regional and multilateral agreements entered regarding transboundary movement of LMOs and summaries of risk assessments of LMOs must be provided through the BCH.

(f) Parties must ensure that risk assessments are carried out for decisions taken under the AIA procedure and must adopt measures for managing any risks identified by risk assessments. They must also monitor and control any new risks that may emerge in the future.

(4) Additional information about the Protocol is available at the following Web sites:

CBD Web site: http://www.biodiv.org/biosafety and Biosafety Clearing-House: http://bch.biodiv.org/Pilot/Home.aspx.
Frequently asked questions are also available at: http://www.biodiv.org/biosafety/faqs.asp
 

 

"The lack of systematic research on the interactions between biology and society is a critical bottleneck in efforts to engage the public in dialogue on biotechnology. This is particularly critical given the fact that advances in biology pose new ecological and ethical issues that are associated with the physical and chemical sciences."

Calestos Juma, 2003

http://usinfo.state.gov/journals/ites/0903/ijee/juma.htm

 

 

South Africa accedes to the Cartagena Protocol

Muffy Koch, Golden Genomics cc, 14 Sept 03

 

The Cartagena Protocol on Biosafety website indicates that SA acceded to the Cartagena Protocol on 14 Aug 03 and the agreement will enter into force for this country on 2 Nov 03. This ends long speculation in the sub-region about whether SA would in fact become a Party to the Protocol. As of today 34 of the 53 African countries have indicated their intention to become Parties to this new international agreement on transboundary movement of living GMOs. Of these, 9 have ratified, 7 have acceded and 18 have signed, but not yet ratified. The Protocol came into effect last week on 11 Sep 03.

 

Parties to the Protocol agree to set up national biosfety structures that will make decisions on transboundary movement of living GMOs and to maintain a biosafety clearing house of information on these structures and decisions. The Parties also agree to enforce an advanced informed agreement process before moving living GMOs into other countries and will, in turn, benefit from the opportunity to assess imported living GMOs before they enter the country. The Protocol excludes living GMOs transferred for research and teaching purposes and has abbreviated requirements for commodities that may contain GM grain.

 

The Global Environmental Facility (GEF) has made funding available to help developing countries develop national biosafety frameworks that comply with their obligations under the Protocol. Over 100 countries are accessing this funding through the UNEP biosafety development project. A further 12 countries are accessing GEF funding through UNEP, World Bank and UNDP to implement biosafety frameworks developed under earlier projects.

 

AfricaBio is planning a workshop in Oct 29th to look at the implications of the Protocol for Parties, non-Parties and trade in the sub-region. Further information can be obtained by emailing africabio@mweb.co.za.

BIG PRIZES FOR SCIENCE PHOTOS

Do you have exciting photographs depicting an aspect of science? Or can you capture the excitement of science and technology on film?

Closing date: 14 Nov 03.

More information can be found at www.saasta.ac.za/science lens

 
 

 

 





 

CBD treaty disastrous

Ted Agres, Scientist.com, 11 Sept 03 (shortened)

 

The first legally binding international agreement governing the shipment of GMO across borders went into effect on 11 Sept 03. The Cartagena Protocol on Biosafety requires that the governments of signatory nations be notified when living GMOs, such as crop plants, are going to be brought into the country with the intention of introducing them into the environment. Critics are already expressing concern about possible trade consequences of the new rules, which are intended to protect native biodiversity, but the protocol is not expected to significantly impact scientific research.

 

However, the biosafety protocol is only one part of a larger treaty, the Convention on Biological Diversity (CBD), which also covers access to indigenous plants and other genetic resources, and so far, scientists and others say, the protocol's parent document has proved misguided at best. "The treaty [CBD] is an absolute disaster for scientists," said a senior UN official on condition of anonymity. "It draws no distinction between scientists bioprospecting for drugs and pharmaceuticals, scientists conducting academic research, and those collecting samples for agricultural research and plant breeding. I feel sorry for the scientists. It's a nightmare."

 

The CBD was concluded at the Earth Summit in Rio de Janeiro in June 1992. Since then, it has been signed by 187 parties, including the US, the UK and most European countries. The US Senate, however, has never ratified the treaty, and the Bush administration appears unlikely to push for passage. Nevertheless, for those countries that have ratified the treaty, including most of the developing world, the CBD establishes a framework to allow access to indigenous plants, animals, and other organisms based on "prior informed consent," under "mutually agreed terms," and to ensure the "fair and equitable sharing of benefits" arising from commercialization and other uses. The treaty leaves it to each country to negotiate its own rules for access and benefit sharing.


Douglas Daly, curator of Amazonian botany at the
New York Botanical Garden, says the problem stems from "bioparanoia"—developing countries believe scientists and researchers want to steal their genetic resources to create drugs and other valuable products and not return any of the profits. "In most diversity-rich countries, there is a lot of concern over biopiracy. Some of it is legitimate but a lot of it is exaggerated," Daly said. "The treaty has led to the criminalization of the biological researcher. Everyone is suspect. As a result, people are not doing research or graduate work in these areas."

 

Even local scientists are not immune. Ricardo Callejas, a biology professor at the University of Antioqua in Medellin, Colombia, described a recent visit he and colleagues made to an Indian reserve in the central Colombian Amazon to research Dipterocarpaceae, a flowering plant believed to have originated in Asia. "The locals were so obsessed by the fact that they somehow were 'owners' of this precious plant that, like little children, they tried very hard to hide everything" about it, Callejas wrote in an e-mail to The Scientist. The researchers were made to wait in the forest while the tribe's chief sent a young boy to fetch a few branches. The scientists were allowed to photograph the plant but not to touch it. Ten minutes later, the boy and branches disappeared and the scientists were told to return to their boat and leave. "None of us was interested in the medicinal properties of this species," Callejas said. "We just wanted to enjoy the experience of knowing and learning. Biodiversity, particularly in poor countries like mine, is very much nowadays linked to multinationals and exploitation. Obviously, science itself is misunderstood and completely distorted."


The CBD has also negatively impacted agricultural research for plant breeding and sample collection, said Cary Fowler, senior adviser to the International Plant Genetic Resources Institute, a consortium of 16 major agricultural research institutes around the world. Member facilities hold the world's largest collections of biodiversity for agriculture, crop-breeding materials, and gene banks.
"Our task has become extremely difficult since passage of the CBD," Fowler said. "A lot of material in our gene bank would be extinct if it had not been collected in the past. But we're finding it harder and harder to collect materials now." Collection samples have dropped from about 30 000 per year to fewer than 5 000 as a direct result of the treaty, Fowler said. "The CBD is both the cause and effect of this mentality."

In light of all these problems, the UN and the governments of some developing countries are starting to recognize the need to change the treaty's implementation. In Apr 02, country representatives met in Bonn to discuss how to improve access and benefit sharing, but "further work is still needed to assist parties through complimentary approaches… such as model agreements and model legislation," the UN's CBD secretariat in Montreal told The Scientist. The Bonn Guidelines will attempt to help countries distinguish between access to genetic resources for taxonomy, collection, research, and commercialization. Member countries have been asked to submit "action plans" to increase access by Feb 04. For Callejas, progress on implementing the CBD must be made quickly. "There is no way that our societies in Latin America will emerge from centuries of poverty while holding a completely distorted view of nature," he said. "Once we start looking at organisms as bank accounts, then we are missing the entire view of what is in front of us. Curiosity of the living world ends and so does the meaning of being here."

 


GM agreement in SADC

CropBiotech Net, 19 Sept 03

 

Fourteen Southern Africa states have agreed to common guidelines on the regulation of GMOs and other products resulting from biotechnology. The 14 member states are Angola, Botswana, Democratic Republic of Congo, Lesotho, Malawi, Mauritius, Mozambique, Namibia, Seychelles, SA, Swaziland, Tanzania, Zambia and Zimbabwe.

The guidelines were adopted last month at a Southern Africa Development Community (SADC) meeting and cover areas such as policy development and regulation of GM crops and GM food, the handling of food aid and measures to increase public awareness of biotechnology and biosafety. The guidelines assert that the region should develop mutual policy and regulatory systems that are based on either the Cartagena Protocol on Biosafety or the African Model Law on Biosafety. The heads of member states also agreed to develop national biotechnology policies and strategies, and to increase their efforts to establish national biosafety regulatory systems. Member states were also urged to commission studies on the implications of biotechnology for agriculture, the environment, public health and socio-economics.

(Ed. It is interesting to read here that the SADC advisors have noted that the agreement must be based on either the Cartagena Protocol or the AU Model Law, recognising that the two are mutually incompatible. With 6 SADC countries already ratifying or acceding to the Protocol and another 6 having signed, it looks like the outdated AU Law will die a natural death.)

 

 

Contaminated organic maize meal withdrawn

Food Standards Agency, UK, 11 Sept 03

 

Two batches of organic maize meal have been voluntarily withdrawn from sale in the UK after tests showed that they contained unusually high levels of fumonisins, a group of undesirable chemicals known as mycotoxins.  The 2 products, Fresh and Wild Organic Maize Meal and Infinity Foods Organic Maize Meal, were tested as part of an on-going survey being carried out by the Food Standards Agency to check for levels of a range of mycotoxins in maize and maize products. Results received so far in the survey for other maize-containing products, such as maize flour and polenta, are not a cause for concern.

Fumonisins have been shown to cause liver and kidney damage in animals after long-term exposure and it is possible that they could have the same effect on humans. While there is no limit for fumonisins in food currently, the European Commission (EC) has proposed a limit of 500 micrograms per kilogram (mcg/kg). The levels found in the 2 maize meal samples are above the proposed EC limit and are considered to be high at 4712 and 20 435 mcg/kg. However, there is unlikely to be any immediate risk to health. The 2 products have been withdrawn from sale as a precaution and the EC has been notified about the results. The Food Standards Agency is now carrying out further testing to see if any other brands are affected. Mycotoxins, like fumonisins, are produced by a range of moulds growing on food crops in the field and in storage. Previous surveys have shown that levels of mycotoxins in food are generally very low. The Food Standards Agency carries out a rolling programme of research and surveys to monitor products that might be affected and takes action when unacceptable levels are found.

GM fish produce Hepatitis vaccine

Checkbiotech, 12 Sep 03 (Via The Life Sciences Network) (shortened)

 

Researchers in Singapore have created zebrafish that produce vaccines in their muscles, and they say the technology could be extended to popular food fish, such as salmon, to do away with the pain of injections. The only catch is that the fish must be eaten raw, as cooking would destroy the vaccine, which is a protein. Associate Professor Gong Zhiyuan from the National University of Singapore's biological sciences department has successfully transferred non-zebrafish genes into the fish, so they produce hepatitis B vaccines. He worked with Nanyang Technological University's Associate Professor William Chen, a hepatitis B expert from the university's school of biological sciences.

Prof Chen says the next step will be to test the sashimi vaccine on animals which can be infected with the human hepatitis B virus, in this case the tree shrew, a small mammal. 'Previous attempts to make such transgenic vaccines in plants and animals haven't been very successful, because they do not produce enough of the protein,' he told The Straits Times. Prof Gong, however, said that his work with fish, which he believes is a world-first, has the advantage of producing high levels of the hepatitis B protein needed. Every kilo of fish muscle, he explained, could produce 27g of it. 'It's also cheaper to culture fish, and there'd be no worry of diseases being transmitted to humans, unlike with mammals such as cows. 'We haven't reached the stage yet where we know how many fish you have to eat for a correct dose of vaccine, but based on the high levels of the protein they produce, it shouldn't be much,' he said.

But Prof Chen cautioned that the edible vaccines are still in the early stage of development and will require years of clinical trials before they can make their way to the dinner plate. So far, a GM animal product has yet to be approved for human consumption. The researchers envisage the edible vaccines could be fed to farm animals and fish in their feed. Prof Gong said: 'It's difficult and time-consuming to give fish injections, so there are not many vaccines available for fish.

Already, researchers around the world have created sheep that produce human proteins in their milk, goats that can be milked for spider-web proteins and other genetically engineered animals. They are also working on producing useful proteins in other animals and even vegetables. Prof Gong, a zebrafish expert, has been working with